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The Effects of 830 nm Light-Emitting Diode Therapy on Acute Herpes Zoster Ophthalmicus: A Pilot

Share this deal using     and earn Addo Bucks when your friends join Addoway or make a purchase. Never again. BIOPTRON has been reported to be beneficial in the improvement of residual scarring remaining as a result of various skin conditions, (e.g. Halves cold sore healing time once the blisters have arrived. The recovery process was slow as compared to that observed after UV (254 nm)-irradiation. In order to estimate the time for wound healing, we measured the duration from the vesicle formation to when the lesion crust fell off. The BioStick heals naturally, thus is completely safe and absolutely harmless to the skin and to the user’s health.

The mean time required for wound healing was 13.14±2.34 days in group B and 15.92±2.55 days in group A (p=0.006). In aggregate, these data suggest that hf-HSV-LIGHT transduction may be useful for induction of immune responses to CLL and other B-cell lymphoid malignancies. A marginal but not statistically significant difference in the VAS scores was observed between the two groups (p=0.095). LED-LLLT was easy and pain-free to apply, and was well-tolerated by all patients. It is used in clinical practice as a supplement to other treatments, including nonablative thermal technology. European Journal of Plastic Surgery, 2002, 24(8); 383. Subsequent studies found that the positive effects of LED therapy were related to the stimulation of the fibroblast activity through the enhancement of the mitochondrial functions.

Work is currently under way to evaluate the effects of UBI on eliminating HIV from blood and blood products. To date, no studies have been published on the specific evaluation of the effects of LED for the treatment of herpes zoster. In this study, we used LED therapy for the treatment of acute herpes zoster ophthalmicus. Subjects are in good health. Similar anti-aromatase effect to progesterone, aspirin also inhibits the COX enzymes which are known to form inflammatory prostagladins from breakdown of polyunsaturated fats. Infrared light (880 nm) penetrates to a depth of about 30-50 mm, which makes it more effective for bones, joints, deep muscle, etc. We defined day 0 as the day that the vesicles began to appear.

Immediately after IPL treatment, one side of the face was treated for 35 s with the LED device. The control group (group A) included 8 men and 6 women, with a mean age of 54.50±4.85 years (range 47~62 years). The experimental group (group B) included 7 men and 7 women, with a mean age of 53.14±4.64 years (range 49~64 years). No statistically significant difference in age, gender or initial severity was observed between the two groups (p>0.05). All patients in both groups received treatment with an antiviral agent (250 mg Famcyclovir) and analgesics three times a day for 7 days. Subjects in group A also received treatment with the conventional methods on days 0, 4, 7, and 10. The conventional treatment consisted of topical washing, cleaning of lesions, and removal of necrotic tissue, as appropriate.

Subjects in group B received the conventional treatment and 830 nm LED phototherapy using HEALITE™ (Lutronic, Goyang, Korea) on days 0, 4, 7, and 10. When and how many times can I treat my cold sore? For estimation of the healing time, the duration from the vesicle formation to when the lesion crust fell off was measured by the same independent blinded dermatologist. Pain was estimated on days 4, 7, 10, and 14. The 10-point visual analogue scale (VAS) (0 for no pain to 10 for very severe pain) was used for the measurement of pain. For statistical analysis, an independent-samples t-test was used for a comparison of the mean healing time, and a repeated-measure of ANOVA test was used for a comparison of the difference in the VAS scores between the two groups. p≤0.05 were considered statistically significant.

The SPSS 12.0 statistical package (SPSS Inc., Chicago, IL, USA) was used for the computation of all data. Low-intensity light therapy, commonly referred to as photobiomodulation, using light in the far-red to near infrared region of the spectrum (630~1,000 nm), modulates numerous cellular functions. Low-power lasers and LEDs are the well-accepted therapeutic tools for use in the treatment of the infected, ischemic, and hypoxic wounds, along with other soft tissue injuries. BIOPTRON Light Therapy can be used in children as a complementary therapy in various types of conditions, such as: Pediatric dermal affections Allergic respiratory diseases and upper respiratory tract infections Musculoskeletal and neurological disorders Skin diseases are common in children; up to 15% of children suffer from allergic eczema and skin infections (caused by viruses and bacteria) occur frequently. Using photobiomodulation, both the accelerated-healing and a greater amount of epithelization in the wound-closure of the skin grafts have been demonstrated in human studies. This “die-off” reaction can, however, occur with any type of treatment including antibiotics. We hypothesized that the positive effects of LED therapy on the wound healing would result in a more rapid healing and less scarring in herpes zoster lesions.

A series of recent studies have demonstrated the anti-inflammatory effects of LED therapy. Subjects who have a history of hypertrophic scars and keloids. Another study found that LED therapy has beneficial effects on the prevention of post-inflammatory hyperpigmentation and scarring6. The infrared photo energy releases nitric oxide from the hemoglobin and possibly surrounding tissue. In addition, chemotaxis and phagocytic activity of leucocytes and macrophages is enhanced on cellular stimulation by this wavelength7. BACKGROUND: The stimulating effect of red and near-infrared (NIR) laser phototherapy on bone regeneration and growth has been shown in a number of in vitro and animal studies. It has been shown to be pain-free, side-effect-free, and well-tolerated by patients of all ages.

In our study, we were able to show that the patients treated with the LED phototherapy achieved faster healing and the lower mean VAS scores from day 4, compared with the control group. However, the difference in the VAS scores between the two groups showed no statistical significance. We think that the reason for the statistically-insignificant difference in the VAS scores was the small number of the enrolled patients. However, p=0.095 has a numerical value of marginal significance. Therefore, we believe that conducting a large scaled study may allow us to draw a statistically significant conclusion in the VAS score difference. The pain reduction may have been the result of the anti-inflammatory effects and the improved wound-healing attributed to the LED therapy. It is also known that the Cold Sore Machine light plays a role in generating powerful antioxidants within the cells.

Some of the potential mechanisms of action were the neurophysiologic effects, release of endogenous opioids, local microcirculatory and angiogenic effects, local anti-inflammatory effects, biochemical marker effects, and cell and soft tissue effects8, 9. We believe that the use of this treatment will also result in a decreased risk of postherpetic neuralgia, which is correlated with acute pain. Although we were not able to determine a clear and precise mechanism of LED phototherapy, this therapy appears to be beneficial, not only for the treatment of chronic and non-healing wounds, but also in the management of acute herpes zoster lesions. In addition, the future double-blinded, large-scaled studies with a long-term follow up period is necessary in order to further evaluate the clinical benefits of LED in the treatment of acute herpes zoster. 1. Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, et al. Effect of NASA light-emitting diode irradiation on wound healing.

J Clin Laser Med Surg 2001;19:305–314. 7. Russell BA, Kellett N, Reilly LR. up to 3 times daily to promote healthy bowel elimination. J Cosmet Laser Ther 2005;7:196–200. 8. Enwemeka CS, Parker JC, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD.

The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 2004;22:323–329. 9. RESULTS: Results showed that 635 nm irradiation and existing COX inhibitors inhibit expression of COX and PGE(2) release. Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 2006;24:158–168.

The Effects of 830 nm Light-Emitting Diode Therapy on Acute Herpes Zoster Ophthalmicus: A Pilot

Herpes Zoster patients often have prodromal symptoms  (prior to rash) of  burning, aching, and/or lancing pain, numbness, tingling, and/or itching prior to the appearance of classic vesicles with an erythematous base that typically follows a unilateral dermatomal distribution. We report 2 cases in which zoster developed in the contralateral dermatome distribution homologous to the surgical site. It lies dormant in the dorsal root ganglia and reactivation may occur years later with variable presentations as Herpes Zoster, or Shingles. We herein present a case of herpes zoster complicated by segmental motor paresis of the abdominal musculature resulting in a pseudohernia. Rash and pain are common in patients who have wound infections and contact dermatitis after surgery, so the possible reactivation of varicella virus might not be prominent in the surgeon’s mind. In our case dermoscopy has proven to be an accessible and easy tool to diagnose such atypical presentation of cutaneous leishmaniasis, and dermatologists in endemic areas should be familiar with its typical dermoscopic features. There was no history suggestive of immune defect.

The mean time required for wound healing was 13.14±2.34 days in group B and 15.92±2.55 days in group A (p=0.006). From day 4, the mean VAS score showed a greater improvement in group B, compared with group A. The patient was prescribed a topical clobetasol cream and oral levocetirizine. Light-emitting diode (LED) therapy is known for its healing and anti-inflammatory properties. No signs of meningeal irritation were present. L.; Altomonte, V. Subsequent studies found that the positive effects of LED therapy were related to the stimulation of the fibroblast activity through the enhancement of the mitochondrial functions.

In addition, the upregulation of procollagen synthesis in human fibroblast cultures and the downregulation of matrix metalloproteinases can be achieved by a variation of the LED fluencies and pulse duration2. Also, the vaccine is being tested in older persons to boost their natural immunity to VZV and to prevent zoster. In this study, we used LED therapy for the treatment of acute herpes zoster ophthalmicus. Our aim was to determine whether the treatment of acute herpes zoster lesions with 830 nm LED therapy would result in a decrease of both the healing time and acute pain. Following the approval by the local ethics committee (C2012020 [715]), 28 consecutive Korean patients with acute herpes zoster lesions localized to the V1 dermatome were randomized to the control or the experimental group (Table 1). Her medical history included migraine headaches. (C, D) Dermoscopic features of the lesions, including erythema, hyperkeratosis, burst star whitish appearance and hairpin vessels.

This case with bilateral asymmetrical herpes zoster in an immunocompetent healthy adult emphasizes further studies about theory of reactivation of VZV. The control group (group A) included 8 men and 6 women, with a mean age of 54.50±4.85 years (range 47~62 years). The experimental group (group B) included 7 men and 7 women, with a mean age of 53.14±4.64 years (range 49~64 years). The ampicillin was stopped and the patient was put on a short course of oral prednisolone, antipyretics, and topical calamine. All patients in both groups received treatment with an antiviral agent (250 mg Famcyclovir) and analgesics three times a day for 7 days. Magnetic resonance imaging (MRI) of his brain also revealed features of intraparenchymal hemorrhages with no abnormal contrast enhancement in the above-mentioned sites. We describe two patients who developed linear lichenoid chronic GVHD.

Subjects in group B received the conventional treatment and 830 nm LED phototherapy using HEALITE™ (Lutronic, Goyang, Korea) on days 0, 4, 7, and 10. Skin was exposed to 830 nm wavelength light at a setting of 55 mW/cm2 for 10 minutes twice per week. For estimation of the healing time, the duration from the vesicle formation to when the lesion crust fell off was measured by the same independent blinded dermatologist. Pain was estimated on days 4, 7, 10, and 14. The 10-point visual analogue scale (VAS) (0 for no pain to 10 for very severe pain) was used for the measurement of pain. For statistical analysis, an independent-samples t-test was used for a comparison of the mean healing time, and a repeated-measure of ANOVA test was used for a comparison of the difference in the VAS scores between the two groups. The patient tolerated the procedure well.

The SPSS 12.0 statistical package (SPSS Inc., Chicago, IL, USA) was used for the computation of all data. Low-intensity light therapy, commonly referred to as photobiomodulation, using light in the far-red to near infrared region of the spectrum (630~1,000 nm), modulates numerous cellular functions. Low-power lasers and LEDs are the well-accepted therapeutic tools for use in the treatment of the infected, ischemic, and hypoxic wounds, along with other soft tissue injuries. At the cellular level, photobiomodulation can modulate fibroblast proliferation and attachment, as well as the synthesis of collagen. Using photobiomodulation, both the accelerated-healing and a greater amount of epithelization in the wound-closure of the skin grafts have been demonstrated in human studies. Findings in the literature also show that the LED therapy is known to support and speed up the healing of chronic leg ulcers, including the diabetic, venous, arterial, and pressure ulcers3, 4. Dexamethasone was given for a period of 7 days and acyclovir for 14 days (started on day 2 of hospitalization).

A series of recent studies have demonstrated the anti-inflammatory effects of LED therapy. The findings from one study conducted with the arachidonic acid-treated human gingival fibroblast suggest that 635 nm irradiation inhibits prostaglandin 2 synthesis in a fashion similar to inhibition by cyclooxygenase inhibitors5. Another study found that LED therapy has beneficial effects on the prevention of post-inflammatory hyperpigmentation and scarring6. Irradiation at 830 nm has accelerated fibroblast transformation and mast cell degranulation. In addition, chemotaxis and phagocytic activity of leucocytes and macrophages is enhanced on cellular stimulation by this wavelength7. LED phototherapy with planar arrays of 830 nm diodes is delivered in a hands-free manner. It has been shown to be pain-free, side-effect-free, and well-tolerated by patients of all ages.

In an immunocompetent patient and an uncomplicated surgical case, and with the absence of classical features of wound infection, bacterial involvement is less likely. However, the difference in the VAS scores between the two groups showed no statistical significance. We think that the reason for the statistically-insignificant difference in the VAS scores was the small number of the enrolled patients. However, p=0.095 has a numerical value of marginal significance. Therefore, we believe that conducting a large scaled study may allow us to draw a statistically significant conclusion in the VAS score difference. The pain reduction may have been the result of the anti-inflammatory effects and the improved wound-healing attributed to the LED therapy. Recent reviews concluded on the strong evidence of the low-level laser therapy modulating the inflammatory process and relieving acute pain in the short-term.

Some of the potential mechanisms of action were the neurophysiologic effects, release of endogenous opioids, local microcirculatory and angiogenic effects, local anti-inflammatory effects, biochemical marker effects, and cell and soft tissue effects8, 9. We believe that the use of this treatment will also result in a decreased risk of postherpetic neuralgia, which is correlated with acute pain. Although we were not able to determine a clear and precise mechanism of LED phototherapy, this therapy appears to be beneficial, not only for the treatment of chronic and non-healing wounds, but also in the management of acute herpes zoster lesions. In addition, the future double-blinded, large-scaled studies with a long-term follow up period is necessary in order to further evaluate the clinical benefits of LED in the treatment of acute herpes zoster. 1. Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, et al. Effect of NASA light-emitting diode irradiation on wound healing.

J Clin Laser Med Surg 2001;19:305–314. 7. Russell BA, Kellett N, Reilly LR. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation. J Cosmet Laser Ther 2005;7:196–200. 8. Enwemeka CS, Parker JC, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD.

The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 2004;22:323–329. 9. Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes-Martins RA. Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 2006;24:158–168.