Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and
The B and T lymphocyte attenuator (BTLA) appears to act as a negative regulator of T cell activation and growth. Unlike the simplexviruses of other primate species, only the unique short region of the HVS1 genome is bounded by inverted repeats. However, Ro 09-0198 was found to be quite the same compound as lanthiopeptin in all respects. Truncated BHV-1 gD (tgD) was efficiently secreted into the culture medium as a 68 kDa protein using either the yeast alpha prepro or native BHV-1 gD signal sequences. The core fold adopted by R17 is unexpectedly similar to that of the M3 chemokine decoy receptor encoded by MHV-68, although, strikingly, neither the location of ligand engagement nor the stoichiometry of binding is conserved, suggesting that their functions evolved independently. Our research challenges and tries to advance the current research of HSV-1 nucleus interactions by utilizing a novel interdisciplinary approach, which includes biology and biophysics combined with state-of-the-art techniques of imaging, advanced image analysis, and biophysical modelling. Poseview diagrams can be calculated for approximately 92% of the remaining complexes in the PDB.
In contrast, the DRR terminus of both variants contained a simple tandem array of TRSs and a close homolog of a herpesvirus pac-2 signal (GCn-Tn-GCn). The DRR.DRL junction was formed by simple head-to-tail linkage of the termini, yielding an intact cleavage signal, pac-2.x.pac-1, where x is the putative cleavage site. © 2014, American Society for Microbiology. ► Portal involved in the initiation of HSV-1 capsid assembly. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.