How are our body’s hidden viruses like little green army men? The exact areas and types of sores vary depending on the type of herpes, with oral herpes normally presenting near the lips and mouth, and genital herpes normally presenting on the genitalia. Although they are not necessarily automatic grounds for the rejection of your application, they may make you unsuitable to commence training. It is very, VERY common. In the military you get routine AIDS/HIV checks. In 69 B.C., silver nitrate was described in the contemporary pharmacopoeia. The popularity of medicinal silver especially arose throughout the Middle East from 702 A.D.
through 980 A.D. Having over 4,000 locations nationwide, you can effortlessly find the most convenient lab for you. Paracelsus (circa 1520) extensively used silver medicinally, and later Caradanus, Pareus, and Sala also used it. For example, Angelus Sala used silver nitrate to successfully treat chorea, tabes dorsalis (syphilis), and, it is doubtable, epilepsy. Testing of the suicide transport molecule, Ricin, supported the idea that such molecules could eliminate the pain signaling nerve endings from a neuroma and lead to a significant reduction of neuroma tenderness. It is widely thought that during the Middle Ages silver utensils and goblets contributed a bluish-hue to the skin-tone of the upper class, resulting in the term “blue-bloods.” Plausibly, “born with a silver spoon in his mouth” was coined during that time for the same reason, as an attribute for describing the good fortune of being healthy more than being wealthy. Both these countries are doing the exact same thing: paying people to promote their government’s message online.
During the wars with Napoleon, the armies of Tsar Alexander used water casks lined with silver to clean drinking water from rivers and streams. This practice by the Imperial Russian army was continued through World War I and by some units in the Soviet Army in World War II. The immune army has a magnificent communication system. He found a stable, intermediate state of matter, and was able to describe it. Your body eventually fights the viral army men back to their safe, hidden base of “latency”. He applied the term “colloidal” (from kolla = glue) to this intermediate state, as glue, gelatin, and related substances were the most obvious to him as being in this unique state. The Swiss botanist von Nageli recorded one of the amazing discoveries of the nineteenth century in 1869.
Von Nageli coined the term “oligodynamic” to describe the microbiocidal properties of a metal hydrosol (e.g. copper, silver and tin) at minute concentrations. , In 1884, Crede introduced the use of 1% silver nitrate for the prevention of ophthalmia neonatorum. By 1897, silver nitrate began to be used in America to prevent blindness in newborns and is still used today. , By 1910, Henry Crookes had documented that certain metals, when in a colloidal state, had strong germicidal action, but were harmless to human beings. The oligodynamic concept has motivated the development of many antimicrobial processes and products. One of the water purification developments that took place in 1928 was the development of katadyn silver, described as a porous metallic, spongy mesh that attempts to maximize surface area.
This silver meshwork also contains a small quantity of gold or palladium. The molecular activation of Ras by ligase-mediated neurofibromin degradation represents a landmark discovery in understanding the underpinnings of this disease and its progression. During the last century, advances in pharmacological manufacturing methods sought to harness this time-valued strategy expressed in nearly all silver formulations. Yet early manufacturing methods rarely created high quality, homogenous oligodynamic Ag +. Nevertheless, more than 96 different silver medicinals (many used intravenously) were in use prior to 1939, as documented by The Council on Pharmacy and Chemistry of the American Medical Association. A project begun at the State University of New York by Robert Becker and associates involved a silver nylon product in the early 1970’s. The immune army also guards strategic entry points to the body, such as the respiratory and gastrointestinal tracts.
Instead, it lead to the revolutionary discoveries by Becker of silver’s unique antimicrobial properties, and his discovery that silver ions could induce fibrocytes to dedifferentiate into stem cells and back again. One of Becker’s research associates, A. Bart Flick, continued work in this area for professional and commercial applications. As a result, Flick has filed patents in 1994, 1996 and 2000 for silver-based wound dressings that are far superior to anything that has ever been available before. He has also obtained approval for these dressing from the US Food and Drug Administration. Because of the success of these silver dressings, many other medical product manufacturers have filed for their own parallel products. In the early 1970’s silver topical salves, such as silver sulfadiazine, provided superior control and prophylaxis in severe burn cases.
Today, multiple drug resistant (MDR) microbes are challenging this formulation’s effectiveness, but we shall review how state-of-the-art silver protocols and formulations offer superior protection against microbial strategies for acquiring resistance. To date, absolute microbial resistance to medicinal silver has not been scientifically established. Several studies indicated that some bacterial species have physiological mechanisms that circumnavigate silver’s toxicity. Although it is clear that some pathogens have mechanisms to survive exposure to silver, these mechanisms are limited when compared to higher life forms. Herein lie all the clues necessary to identify strategic silver therapeusis that pathogens are unlikely to survive. Dr. These salves advanced the science of “silver salt-derived” Ag + delivery and effectiveness in the mid 1960’s.
Then, during the mid 1970’s, several papers were published that utilized electrically activated silver probes as delivery systems for targeted oligodynamic Ag + strategies. The interest in such strategies continues to grow to the present, with high efficacy being obtained for viral vectors such as HIV, and resistant bone and dental infection. The medical literature of the early 20 th century regarding silver provides an important cautionary lesson from the past. The battle spreads to other parts of the body (a disease process called metastasis). This fault undermined their definitive knowledge about silver. Correct and in-context discernment of silver’s Therapeutic Threshold remains illusive to most investigators even today. This “box” perception about silver will continue to lose its limitations as technology continues to prove itself outside of that box in the coming decades.
Clinical reports on silver medicinals began to flood into the various medical journals worldwide at the start of the last century. Initially, the Journal of the American Medical Association took a negative position. But within 11 years, a true revolution in medical practice with silver medicinals occurred that did not subside until the U.S. government’s purchase of the patent rights to penicillin (circa 1940). Throughout this time period (1920 through 1942), JAMA articles were replete with oral (per os) and intravenous clinical reports of the efficacy and side effects of silver medicinals. In tandem with research in America, Great Britain published prominently in such respected journals as The Lancet and the British Medical Journal. Perhaps the first definitive attempt to comprehensively evaluate the efficacy and variety of silver medicinals was published by the Department of Pharmacology of the Medical School of Western Reserve University, Cleveland, circa 1923.
In terms of efficacy, this landmark study arguably established “silver nitrate” as the benchmark for all silver medicinals. Unfortunately, the excitement this study produced simultaneously placed at risk subgroups of patients susceptible to symptoms of argyria. Such tumors can cause pain, paralysis, seizures, hearing loss, and death. Oligodynamic (picoscale) surface area enables maximal exposure of silver particles in the least amount of volume, thus achieving potency several orders of magnitude over suspensions of much higher ppm- silver speciations (which necessarily manifest inferior surface area exposures). In other words, technology today can produce smaller quantities of silver that are vastly more potent than was ever historically possible. The result is a dramatic elucidation of the Therapeutic Index, resulting in unprecedented safety, efficacy, and dimension to protocol parameters. For example, beginning in 1970 at the University of Wisconsin, under contract from NASA to determine the biocidal effects of silver, researchers were able to determine that lethal effects of silver ions could be reliably reproduced at concentrations of only 250-ppb when exposed to infectious agents over two hours or less in vitro.
These researchers even found that even 50-ppb over four hours or less achieved a significant biocidal effect. The University study with laboratory-produced silver ions worked extremely well, although the extinction times were long. Follow-on investigations of these early silver medicinals failed to exert adequate lethal effects upon antibiotic resistant infectious organisms. However, as technology advanced, these highly resistant organisms were again found to succumb to the lethal effects of new silver medicinals. Additionally, extinction times proved to be dramatically lessening. At the height of its popularity (from 1900 through 1940), a fair estimate of humans given intravenous silver medicinals worldwide exceeded several million. The shear scale of its utilization defined and confirmed silver medicinals as effective anti-microbials.
During my training as a medical student, I had an opportunity to witness several of my elder attending physicians using various silver formulas in their clinical practice. It was fascinating to me that silver medicinals were widely used by one generation of clinicians, yet this therapeutic approach simply ended by my generation. Why? In terms of safety and efficacy, was there a justification for abandonment of this approach? One recent and noteworthy in vivo study published in the Journal of Clinical Ultrasound (2000) reported on a protocol involving puncture, aspiration, injection, and re-aspiration (PAIR) with silver nitrate directly into hepatic hydatid cysts with beneficial long-term results. Other preliminary evidence in vivo suggests that both hepatitis-C virus (HCV) and HIV , and other viral vectors, as well as in vitro studies on herpes, and the worst bacterial scourges (i.e., antibiotic resistant disease vectors) may become events of the past via the judicious and strategic use of a state-of-the-art silver medicinal and delivery system. At least 50% of NF1 patients have one or more skeletal abnormalities, including kyphoscoliosis, pseudoarthrosis, and osteoporosis, but only limited efforts have been focused on understanding the underlying molecular mechanisms.
These silver coatings are very effective at blocking bacteria, such as E coli and S aureus, from entering the body along a catheter pathway. At the present time, in vivo studies concerning the efficacy of oral (per os) and intravenous use of state-of-the-art picoscale oligodynamic Ag + are just beginning. Given the high technology formulated silver product now available, this promises to be an exciting time. Concerning inferior grade silver [salt] medicinals, or “large particle size (i.e., 0.1 microns or larger)” colloidal silver preparations, it may be said that unless educational initiatives are undertaken, history is apt to repeat itself — needless iatrogenic events with such products will gestate a new wave of preventable argyric cases. Thomas Graham was a physical chemist honored as the founder of colloid chemistry. He is known for contributions to diffusion phenomena in liquids leading to the colloidal state; he coined the terms “colloid” and “dialysis.” Graham also contributed to the understanding of gas diffusion, including the law that the velocities of gases are inversely proportional to the square roots of their densities. Gettler, AO, Rhoads, CP, Weiss, S, “A Contribution to the Pathology of Generalized Argyria with a Discussion on the Fate of Silver in the Human Body,” Am J Pathol, 1927; 3:63151.
Pilcher, JD, Sollmann, T, “Organic, Protein and Colloidal Silver Compounds: Their Antiseptic Efficiency and Silver-Ion Content as a Basis for Their Classification,” The Journal of Laboratory and Clinical Medicine, 1923; p. 301-10. In vitro investigations published on letterheads from Departments of Microbiology, Pathology, Infectious Diseases, Immunology, and Biology. Etc… from such universities as: Johns Hopkins, Northwestern Univ. Medical School, Queen’s University, University of Arkansas for Medical Sciences, Georgetown University Medical Center, NYU Medical Center, University of Nebraska, University of Massachusetts, etc…circa 1996-1998. Modak, SM, Sampath, L, Fox, CL, “Combined Use of Silver Sulfadiazine and Antibiotics as a Possible Solution to Bacterial Resistance in Burn Wounds,” J Burn Care, July/August, 1988; 9(4): 359.