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Biologics Don’t Increase Herpes Zoster Risk : Dermatology News

Abstract: The global burden of disease associated with Varicella-Zoster Virus (VZV), the aetiological agent of chickenpox and shingles, can no longer be considered insignificant. While the U.S. Patients with depressive disorders principally be enduring decreased amounts of these two neurochemicals. The downward trend in varicella has continued in the United States through 2005 with an approximately 90% decline in incidence from 1995 in active surveillance sites with high vaccine coverage (CDC, unpublished data). This was a real-world patient population, 53% of whom were female, in contrast to the highly selected populations in randomized clinical trials, which are typically 65%-69% male. Editor’s comment: This study revealed that age, stress level, marriage, occupation, asthma, atopic dermatitis, pulmonary tuberculosis, depression, thyroid disease, and parental AR history affected the prevalence of AR. Eighteen percent of patients were on systemic corticosteroids at some point during the study; that medication was associated with a herpes zoster rate of 25.7/1,000 patient-years of exposure.

Increases were comparable for males and females. Eighteen percent of psoriasis patients were on systemic corticosteroids at some point during the study period; that medication was associated with a herpes zoster rate of 25.7/1,000 patient-years of exposure. They further demonstrated that treatment with a calcilytic agent prevented the excessive activity of CaSR in airway tissue, opening a new and exciting potential treatment for asthma. Cohen, director of the department of quality measures at Clalit and a dermatologist at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Event was captured within 30 days posterior to the end of each treatment episode. Neurological complications, by far the most common type of complication, are dominated by a persistent pain syndrome known as postherpetic neuralgia (PHN). Remicade therapy was associated with a 1.8-fold increase in risk, a trend that did not achieve statistical significance (P =.09).

Dr. Cohen and his coinvestigators conducted this study because, even though the biologic agents are recognized as conferring increased risk of tuberculosis and serious bacterial infections, very little is known about their association, if any, with viral infections.