anti-Herpes Simplex Virus II, Glycoprotein G-2 antibody | Mouse Herpes Simplex Virus II, Glycoprotein G-2
Herpes simplex virus type 1 (HSV-1) and HSV-2 are highly prevalent viruses that cause a variety of diseases, from cold sores to encephalitis. The synthesis and post-translational maturation of HSV type-2 (HSV-2) glycoproteins were studied using an ionophore, monensin. We investigated whether the gD-HVEM interaction during priming changes lymphocyte recall responses in the murine intravaginal model. METHODS HSV-2 DNA was extracted and used as template in polymerase chain reactions to amplify gD2 gene. Reconstitute by adding 0.25ml distilled water and storing at 2-8øC. In study 1, immunization with gC2, gD2, or both immunogens significantly reduced the frequency of genital lesions, with the bivalent vaccine showing the greatest protection. This suggests a possible role for phage-displayed peptides in inducing protective immunity against pathogens and provides a model system for investigating the underlying mechanisms.
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